Predictive factors for pancreatic fistula following pancreatectomy

Published on Oct 1, 2014in Langenbeck's Archives of Surgery2.093
· DOI :10.1007/s00423-014-1220-8
Matthew T. McMillan19
Estimated H-index: 19
(UPenn: University of Pennsylvania),
Charles M. Vollmer30
Estimated H-index: 30
(UPenn: University of Pennsylvania)
Background Postoperative pancreatic fistula is a significant contributor to morbidity following proximal and distal pancreatic resections. In recent decades, the incidence of fistula has ranged from 2 to 33 %; however, the consistent identification of risk factors has been difficult due to significant variability in the definition of pancreatic fistula.
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#2William E. Fisher (BCM: Baylor College of Medicine)H-Index: 42
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#1Matthew T. McMillan (UPenn: University of Pennsylvania)H-Index: 19
#2John D. Christein (UAB: University of Alabama at Birmingham)H-Index: 31
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Background Postoperative pancreatic fistula is a major contributor to complications and death associated with pancreatic resection. Pasireotide, a somatostatin analogue that has a longer half-life than octreotide and a broader binding profile, decreases pancreatic exocrine secretions and may prevent postoperative pancreatic fistula. Methods We conducted a single-center, randomized, double-blind trial of perioperative subcutaneous pasireotide in patients undergoing either pancreaticoduodenectomy ...
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#1George Van Buren (BCM: Baylor College of Medicine)H-Index: 18
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Abstract To test by randomized prospective multicenter trial the hypothesis that pancreaticoduodenectomy (PD) without the use of intraperitoneal drainage does not increase the frequency or severity of complications. Some surgeons have abandoned the use of drains placed during pancreas resection. We randomized 137 patients to PD with (n = 68, drain group) and without (n = 69, no-drain group) the use of intraperitoneal drainage and compared the safety of this approach and spectrum of complications...
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#1Benjamin C. Miller (UPenn: University of Pennsylvania)H-Index: 5
#2John D. Christein (UAB: University of Alabama at Birmingham)H-Index: 31
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#2Rahul S. Koti (UCL: University College London)H-Index: 16
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