Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature
Abstract
An efficient optimization method for the crystallization of biological macromolecules has been developed and tested. This builds on a successful high‐throughput technique for the determination of initial crystallization conditions. The optimization method takes an initial condition identified through screening and then varies the concentration of the macromolecule, precipitant, and the growth temperature in a systematic manner. The amount of...
Paper Details
Title
Efficient optimization of crystallization conditions by manipulation of drop volume ratio and temperature
Published Date
Apr 1, 2007
Journal
Volume
16
Issue
4
Pages
715 - 722
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