Hunger Does Not Diminish Over Time in Mice Under Protracted Caloric Restriction

Caloric restriction (CR) is the only nongenetic manipulation known to reliably prolong life-span. Modeling suggests that humans would need to restrict their intake for many years to reap any lifespan benefits. The feasibility of such prolonged restriction may hinge on whether hunger diminishes with the time period spent restricted. We used the magnitude of hyperphagia on release from restriction as a bioassay of hunger in restricted mice. During...