Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Abstract
The regulatory events guiding progenitor activation and differentiation in adult white adipose tissue are largely unknown. We report that induction of brown adipogenesis by β3-adrenergic receptor (ADRB3) activation involves the death of white adipocytes and their removal by M2-polarized macrophages. Recruited macrophages express high levels of osteopontin (OPN), which attracts a subpopulation of PDGFRα+ progenitors expressing CD44, a receptor...
Paper Details
Title
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Published Date
Sep 1, 2013
Journal
Volume
18
Issue
3
Pages
355 - 367
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Notes
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