Synthesis, Structural Characterization, and Preliminary Biological Characterization of Organotin Polyethers Derived from Hydroquinone and Substituted Hydroquinones
Published on Mar 1, 2009in Journal of Inorganic and Organometallic Polymers and Materials 1.64
· DOI :10.1007/s10904-008-9220-1
A variety of dibutyltin polyethers have been synthesized employing the interfacial polymerization technique. The products are polymers with degrees of polymerization ranging from 60 to 390. Infrared spectral and mass spectral results are consistent with the proposed structure. The products show good inhibition of a variety of cancer cells including those associated with bone, breast, prostrate, and lung cancers. Some also show good viral inhibition of the HSV-1 (herpes simplex) and Vaccina (small pox) viruses with those derived from electron rich hydroquinone derivative being most active. Hydroquinone-derived polymers containing electron withdrawing groups exhibit inhibition of a variety of gram positive and gram negative bacteria.