MARCKS Regulates Growth, Radiation Sensitivity, and Is a Novel Prognostic Factor for Glioblastoma

The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is crucial to many aspects of cell growth and survival in glioblastoma (GBM). Phosphatidyl inositol bisphosphate (PIP2) is converted to the triphosphate (PIP3) by PI3K which leads to Akt activation. Myristoylated Alanine Rich C-Kinase Substrate (MARCKS) is capable of sequestering PIP2 at the membrane via electrostatic interactions. We thus hypothesized that the MARCKS protein could...