Crystallization of antibody fragments and their complexes with antigen
Abstract
null null Immunoglobulins, myeloma light chains and their fragments, and Fab fragments from monoclonal antibodies of predefined specificity have been crystallized as single components or complexed with their specific antigens. The intersegmental flexibility of antibody molecules has imposed the strategy of attempting to crystallize their Fab and Fc fragments separately. Intrasegmental mobility in Fabs has not been an obstacle to their...
Paper Details
Title
Crystallization of antibody fragments and their complexes with antigen
Published Date
Jul 2, 1988
Journal
Volume
90
Pages
213 - 221
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