Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis

Importance

Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.

Objective

To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA.

Design, Setting, and Patients

A 2-year randomized, placebo-controlled,...