Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
Abstract
Susceptibility to complex disease appears to be partly mediated by heritable differences in gene expression. Where cis-acting effects on a gene's expression influence disease susceptibility, other genes containing polymorphism with a trans-acting effect on expression of that gene may also be expected to modulate risk. Use of the expression of an identified disease gene as an endophenotype for quantitative linkage analysis may therefore provide a...
Paper Details
Title
Cis- and trans- loci influence expression of the schizophrenia susceptibility gene DTNBP1
Published Date
Jan 8, 2008
Journal
Volume
17
Issue
8
Pages
1169 - 1174
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