Structures of complement component C3 provide insights into the function and evolution of immunity
Abstract
The mammalian complement system is a phylogenetically ancient cascade system that has a major role in innate and adaptive immunity. Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we present crystal structures of native C3 and its final major proteolytic fragment C3c. The structures reveal thirteen domains, nine of which were...
Paper Details
Title
Structures of complement component C3 provide insights into the function and evolution of immunity
Published Date
Sep 1, 2005
Journal
Volume
437
Issue
7058
Pages
505 - 511
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History