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Investigations on the protective role of passively transferred antibodies against avian metapneumovirus infection in turkeys

Published on Dec 1, 2009in Avian Pathology1.96
· DOI :10.1080/03079450903349204
Dennis Rubbenstroth16
Estimated H-index: 16
,
Silke Rautenschlein20
Estimated H-index: 20
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Abstract
The avian metapneumovirus (aMPV) is the causative agent of an acute respiratory disease in turkeys, which causes considerable economic losses to the poultry industry. Currently attenuated live and inactivated vaccines are widely used to control the disease, but vaccine breaks are frequently observed. For improvement of current vaccination strategies it is necessary to gain enhanced knowledge of the immune mechanisms against aMPV infection. Field observations suggest that vaccine-induced aMPV-specific antibodies are not indicative for protection. In the present study we investigated the role of antibodies in protection of turkeys against aMPV. In two experiments, commercial turkey poults received aMPV-specific antibodies by intravenous injection. The antibody transfer resulted in increased antibody levels in the sera. Virus-specific antibodies were also detected on mucosal surfaces such as the trachea, conjunctivae and gall bladder. Turkeys were subsequently challenged with a virulent aMPV subtype A strain...
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  • Citations (11)
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References58
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#1Darrell R. Kapczynski (USDA: United States Department of Agriculture)H-Index: 26
#2Laura E. Leigh Perkins (USDA: United States Department of Agriculture)H-Index: 6
Last.Holly S. Sellers (USDA: United States Department of Agriculture)H-Index: 16
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#1Ra Mi Cha (UMN: University of Minnesota)H-Index: 6
#2Mahesh Khatri (UMN: University of Minnesota)H-Index: 14
Last.J. M. Sharma (UMN: University of Minnesota)H-Index: 40
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#1E. Catelli (UNIBO: University of Bologna)H-Index: 12
#2Cecchinato Mattia (UNIBO: University of Bologna)H-Index: 6
Last.C. J. Naylor (University of Liverpool)H-Index: 17
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#1M Van Loock (Katholieke Universiteit Leuven)H-Index: 5
#2Karolien Loots (Katholieke Universiteit Leuven)H-Index: 5
Last.Daisy Vanrompay (UGent: Ghent University)H-Index: 31
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Cited By11
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#1J.A. Vizcarra (A&M: Texas A&M University)H-Index: 14
#2H. Wright (A&M: Texas A&M University)H-Index: 1
Last.A. Vizcarra (A&M: Texas A&M University)H-Index: 1
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#1Jorge Luis Chacón (USP: University of São Paulo)H-Index: 10
#2Matheus Y. Mizuma (USP: University of São Paulo)H-Index: 2
Last.Antonio José Piantino Ferreira (USP: University of São Paulo)H-Index: 16
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#1C. J. Naylor (University of Liverpool)H-Index: 17
#2C. Lupini (UNIBO: University of Bologna)H-Index: 3
Last.Paul A. Brown (University of Liverpool)H-Index: 4
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