An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation
Abstract
Summary null V(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications characteristic of active chromatin, including trimethylation of histone H3 on lysine 4 (H3K4me3). Engagement of H3K4me3 by a plant homeodomain (PHD) in RAG-2 promotes recombination in vivo and stimulates DNA...
Paper Details
Title
An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation
Published Date
Jan 6, 2015
Journal
Volume
10
Issue
1
Pages
29 - 38
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