Prediction of solubility of lysozyme in lysozyme –NaCl–H2O system with artificial neural network

Modeling and prediction of protein solubility is a key to developing the protein crystal growth and crystallization process. In this paper a back propagation network was used for predicting the solubility of protein in lysozyme-NaCl-H2O system. It was found that properly selected and trained neural network could fairly represent the dependence of protein solubility on the pH, salt concentration, and temperature. The RMSD (root mean square...