Linkage disequilibrium — understanding the evolutionary past and mapping the medical future

Linkage disequilibrium was once a concept used little outside population genetics. However, in the genomics era it has become fundamental to our understanding of the genetic variation that is behind complex traits and evolutionary change. Linkage disequilibrium — the nonrandom association of alleles at different loci — is a sensitive indicator of the population genetic forces that structure a genome. Because of the explosive growth of methods...