Human mutation rate associated with DNA replication timing
Abstract
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome. All classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA...
Paper Details
Title
Human mutation rate associated with DNA replication timing
Published Date
Mar 15, 2009
Journal
Volume
41
Issue
4
Pages
393 - 395
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