Comparative modeling and molecular docking studies of d-Alanine:d-alanine ligase: a target of antibacterial drugs

d-Alanine:d-alanine ligase (Ddl) catalyzes the ATP-driven ligation of two d-alanine (d-Ala) molecules resulting in the formation of d-alanyl:d-alanine dipeptide. Inhibition of Ddl prevents bacterial growth, which makes this enzyme an attractive and viable target for searching effective antimicrobial drugs. Current study aimed at the discovery of potent inhibitors against Strepotococcus sanguinis SK36 Ddl (SsDdl). Using comparative molecular...