Structural and Functional Mechanisms of CRAC Channel Regulation

In many animal cells, stimulation of cell surface receptors coupled to G proteins or tyrosine kinases mobilizes Ca2 + influx through store-operated Ca2+-release-activated Ca2 + (CRAC) channels. The ensuing Ca2 + entry regulates a wide variety of effector cell responses including transcription, motility, and proliferation. The physiological importance of CRAC channels for human health is underscored by studies indicating that mutations in CRAC...