Review paper
Structural and Functional Mechanisms of CRAC Channel Regulation
Abstract
In many animal cells, stimulation of cell surface receptors coupled to G proteins or tyrosine kinases mobilizes Ca2 + influx through store-operated Ca2+-release-activated Ca2 + (CRAC) channels. The ensuing Ca2 + entry regulates a wide variety of effector cell responses including transcription, motility, and proliferation. The physiological importance of CRAC channels for human health is underscored by studies indicating that mutations in CRAC...
Paper Details
Title
Structural and Functional Mechanisms of CRAC Channel Regulation
Published Date
Jan 1, 2015
Journal
Volume
427
Issue
1
Pages
77 - 93
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