One-pot stereospecific construction of cis-clerodane skeleton by means of doubly stereocontrolled cyclization: Total synthesis of linaridial

Doubly stereocontrolled cyclization of the allylsilane derivative 1 followed by trapping of the enolate with ClCH2SMe gives in one-pot manner the decalone derivatve 5 in which all of the four contiguous diastereomeric centers of cis-clerodane skeleton have been secured. The total synthesis of linaridial 4 have been accomplished from...