APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Abstract
The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are incompletely understood. Here we show that transcripts of hundreds of genes undergo site-specific C>U RNA editing in macrophages during M1 polarization and in monocytes in response to hypoxia and interferons. This editing alters the amino acid sequences for scores of proteins, including many that are involved in pathogenesis of viral diseases. APOBEC3A, which...
Paper Details
Title
APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Published Date
Apr 21, 2015
Journal
Volume
6
Issue
1
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