Regulation of T cells by mTOR: the known knowns and the known unknowns
Abstract
Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator of environmental cues critical for the regulation of T cell activation, differentiation, and function. Recent studies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components in the mTOR pathway have provided important insights into the mechanisms involved, and have been informative in defining targets downstream of mTOR...
Paper Details
Title
Regulation of T cells by mTOR: the known knowns and the known unknowns
Published Date
Jan 1, 2015
Journal
Volume
36
Issue
1
Pages
13 - 20
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