Match!

Gene-environment interaction on neural mechanisms of orthographic processing in Chinese children.

Published on Feb 1, 2015in Journal of Neurolinguistics1.247
· DOI :10.1016/j.jneuroling.2014.09.007
Mengmeng Su7
Estimated H-index: 7
(BNU: Beijing Normal University),
Jiuju Wang1
Estimated H-index: 1
+ 6 AuthorsHua Shu41
Estimated H-index: 41
(BNU: Beijing Normal University)
Abstract
The ability to process and identify visual words requires efficient orthographic processing of print, consisting of letters in alphabetic languages or characters in Chinese. The N170 is a robust neural marker for orthographic processes. Both genetic and environmental factors, such as home literacy, have been shown to influence orthographic processing at the behavioral level, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-by-environment interactions on orthographic processing at the behavioral and neural level in a normal children sample. Sixty 12 year old Chinese children from a 10-year longitudinal sample underwent an implicit visual-word color decision task on real words and stroke combinations. The ERP analysis focused on the increase of the occipito-temporal N170 to words compared to stroke combinations. The genetic analysis focused on two SNPs (rs1419228, rs1091047) in the gene DCDC2 based on previous findings linking these 2 SNPs to orthographic coding. Home literacy was measured previously as the number of children's books at home, when the children were at the age of 3. Relative to stroke combinations, real words evoked greater N170 in bilateral posterior brain regions. A significant interaction between rs1091047 and home literacy was observed on the changes of N170 comparing real words to stroke combinations in the left hemisphere. Particularly, children carrying the major allele “G” showed a similar N170 effect irrespective of their environment, while children carrying the minor allele “C” showed a smaller N170 effect in low home-literacy environment than those in good environment.
  • References (74)
  • Citations (9)
📖 Papers frequently viewed together
8 Citations
2011
5 Authors (Xiangzhi Meng, ..., Xiaolin Zhou)
32 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References74
Newest
#1Yuping Zhang (BNU: Beijing Normal University)H-Index: 10
#2Twila TardifH-Index: 25
Last. Zhixiang Zhang (PKU: Peking University)H-Index: 9
view all 8 authors...
This study examined the relations among socioeconomic status (SES), early phonological processing, vocabulary, and reading in 262 children from diverse SES backgrounds followed from ages 4 to 9 in Beijing, China. SES contributed to variations in phonological skills and vocabulary in children's early development. Nonetheless, early phonological and vocabulary abilities exerted equally strong and independent mediation of the SES effects on children's reading achievement by the end of 3rd grade for...
45 CitationsSource
#1Richard C. Anderson (UIUC: University of Illinois at Urbana–Champaign)H-Index: 64
#2Yu-Min Ku (NCU: National Central University)H-Index: 7
Last. Hua Shu (BNU: Beijing Normal University)H-Index: 41
view all 6 authors...
Chinese children's visual representation of characters was tracked with two tasks. The Delayed Copy Character Task required children to reproduce different types of characters and noncharacters after each had been briefly presented. The Detect Component Task required children to find different types of components embedded in sets of characters. Experiment 1 showed that by late first grade some children are aware of the internal structure of Chinese characters and are beginning to encode characte...
36 CitationsSource
#1Gwendoline Mahé (CNRS: Centre national de la recherche scientifique)H-Index: 5
#2Anne Bonnefond (CNRS: Centre national de la recherche scientifique)H-Index: 14
Last. Nadège Doignon-Camus (CNRS: Centre national de la recherche scientifique)H-Index: 9
view all 5 authors...
Abstract Efficient reading relies on expertise in the visual word form area, with abnormalities in the functional specialization of this area observed in individuals with developmental dyslexia. We have investigated event related potentials in print tuning in adults with dyslexia, based on their N170 response at 135–255 ms. Control and dyslexic adults performed a lexical decision task with symbol strings and four sets of word-like stimuli (consonant strings, pseudowords, low frequency words and ...
33 CitationsSource
#1Katarzyna JednorógH-Index: 17
#2Irene AltarelliH-Index: 9
Last. Franck RamusH-Index: 36
view all 8 authors...
There was an error in affiliation 1 for authors Katarzyna Jednorog, Irene Altarelli, and Franck Ramus. Affiliation 1 should be: Laboratoire de Sciences Cognitives et Psycholinguistique, Departement d’Etudes Cognitives, Ecole Normale Superieure, Ecole des hautes etudes en sciences sociales, Centre national de la recherche scientifique, Paris, France
37 CitationsSource
#1Jing Zhao (CAS: Chinese Academy of Sciences)H-Index: 11
#2Su Li (CAS: Chinese Academy of Sciences)H-Index: 10
Last. Xu Chu Weng (CAS: Chinese Academy of Sciences)H-Index: 2
view all 6 authors...
Objective The left-lateralized N170, an event-related potential component consistently shown in response to alphabetic words, is a robust electrophysiological marker for reading expertise in an alphabetic language. In contrast, such a marker is lacking for expertise in reading Chinese, because the existing results about the lateralization of N170 for Chinese characters are mixed, reflecting complicated factors such as top-down modulation that contribute to the relative magnitudes of N170 in the ...
25 CitationsSource
#1Fahimeh Darki (KI: Karolinska Institutet)H-Index: 8
#2Myriam Peyrard-Janvid (KI: Karolinska Institutet)H-Index: 20
Last. Torkel Klingberg (KI: Karolinska Institutet)H-Index: 47
view all 5 authors...
Background Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown. Methods We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration ( DYX1C1 , DCDC2 , KIAA0319 ) and white matter volume in a cohort of 76 children and young adults from the general population. Results We found that all three genes contained polymorphisms that were sign...
100 CitationsSource
#1Yuping Zhang (BNU: Beijing Normal University)H-Index: 10
#2Jun Li (BNU: Beijing Normal University)H-Index: 13
Last. Hua Shu (BNU: Beijing Normal University)H-Index: 41
view all 11 authors...
Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear. Here, we investigated the contribution of this gene to reading, with a focus on orthographic skills, in a sample of 284 unrelated Chinese children aged 5 to 11 years who were participating in the Chinese Longitudinal Study of Reading Development. We tested this association using a quantitative approach for Chinese character reading, Chinese character di...
15 CitationsSource
#1Katarzyna Jednoróg (Nencki Institute of Experimental Biology)H-Index: 17
#2Irene Altarelli ('ENS Paris': École Normale Supérieure)H-Index: 9
Last. Franck Ramus ('ENS Paris': École Normale Supérieure)H-Index: 36
view all 8 authors...
Children’s cognitive abilities and school achievements are deeply affected by parental socioeconomic status (SES). Numerous studies have reported lower cognitive performance in relation to unfavorable environments, but little is known about the effects of SES on the child’s neural structures. Here, we systematically explore the association between SES and brain anatomy through MRI in a group of 23 healthy 10-year-old children with a wide range of parental SES. We confirm behaviorally that langua...
145 CitationsSource
#1Hong Li (BNU: Beijing Normal University)H-Index: 14
#2Hua Shu (BNU: Beijing Normal University)H-Index: 41
Last. Hong PengH-Index: 2
view all 5 authors...
Tasks tapping visual skills, orthographic knowledge, phonological awareness, speeded naming, morphological awareness and Chinese character recognition were administered to 184 kindergarteners and 273 primary school students from Beijing. Regression analyses indicated that only syllable deletion, morphological construction and speeded number naming were unique correlates of Chinese character recognition in kindergarteners. Among primary school children, the independent correlates of character rec...
125 CitationsSource
#1Susana Araújo (University of the Algarve)H-Index: 9
#2Inês Bramão (University of the Algarve)H-Index: 7
Last. Alexandra Reis (KI: Karolinska Institutet)H-Index: 23
view all 5 authors...
In this study, event related potentials (ERPs) were used to investigate the extent to which dyslexics (aged 9–13 years) differ from normally reading controls in early ERPs, which reflect prelexical orthographic processing, and in late ERPs, which reflect implicit phonological processing. The participants performed an implicit reading task, which was manipulated in terms of letter-specific processing, orthographic familiarity, and phonological structure. Comparing consonant- and symbol sequences,...
35 CitationsSource
Cited By9
Newest
#1Mengmeng Su (Capital Normal University)H-Index: 7
#1Mengmeng Su (Capital Normal University)
Last. Hua Shu (McGovern Institute for Brain Research)H-Index: 41
view all 10 authors...
Abstract In the present longitudinal study, we investigated the joint effect of early family factors and long-term vocabulary development on the structure of reading-related white matter pathways in adolescents. Seventy-nine children participated in this study. Family environment was measured via parental questionnaire between age 1 and age 3. From age 4 to age 10, children’s vocabulary skills were tested annually. At age 14, diffusion tensor imaging data of the children were collected. Using in...
1 CitationsSource
#1Jing Zhao (Hangzhou Normal University)H-Index: 11
#2Urs Maurer (CUHK: The Chinese University of Hong Kong)H-Index: 25
Last. Xuchu Weng (SCNU: South China Normal University)
view all 4 authors...
How a child’s brain develops specialization for print is poorly understood. One longstanding account is selective neuronal tuning to regularity of visual-orthographic features, which predicts a monotonically increased neural activation for inputs with higher regularity during development. However, we observed a robust interaction between a stimulus’ orthographic regularity (bottom-up input) and children’s lexical classification ability (top-down prediction): N1 response, which is the first negat...
Source
#2Li Hai TanH-Index: 39
Last. Charles A. PerfettiH-Index: 76
view all 3 authors...
Source
The aetiology of developmental dyslexia (DD) is complex; although candidate genes have been suggested, the molecular mechanism and risk factors remain unknown. The KIAA0319 gene is functionally related to neuronal migration and axon growth, and several studies have examined associations between KIAA0319 polymorphisms with DD, but the results remain inconsistent. The sample size affects the results of meta-analysis. The aim of this meta-analysis was to clarify the effect of KIAA0319 polymorphisms...
Source
#1Mengmeng Su ('ENS Paris': École Normale Supérieure)H-Index: 7
#2Jingjing Zhao (SNNU: Shaanxi Normal University)H-Index: 8
Last. Hua Shu (McGovern Institute for Brain Research)H-Index: 41
view all 7 authors...
Abstract Chinese is a logographic language that is different from alphabetic languages in visual and semantic complexity. Thus far, it is still unclear whether Chinese children with dyslexia show similar disruption of white matter pathways as in alphabetic languages. The present study focused on the alteration of white matter pathways in Chinese children with dyslexia. Using diffusion tensor imaging tractography, the bilateral arcuate fasciculus (AF-anterior, AF-posterior and AF-direct segments)...
6 CitationsSource
#1Su Li (CAS: Chinese Academy of Sciences)
#2Li Yin (THU: Tsinghua University)H-Index: 8
To what extent are young children sensitive to individual stroke, the smallest unit of writing in Chinese that carries no phonological or semantic information? The present study examined Chinese kindergartners’ sensitivity to stroke and the contribution of reading ability and age to stroke sensitivity. Fifty five children from Beijing, including 28 4-year-olds (Mage=4.55 years, SD=0.28, 16 males) and 29 5-year-olds (Mage=5.58 years, SD=0.30, 14 males), were administered an orthographic matching ...
Source
#1Xiuhong Tong (Hangzhou Normal University)H-Index: 9
#2Jason Chor Ming Lo (CUHK: The Chinese University of Hong Kong)H-Index: 3
Last. Bonnie Wing-Yin Chow (CityU: City University of Hong Kong)H-Index: 16
view all 8 authors...
Abstract Visual expertise in distinguishing words from objects and word-like stimuli is a fundamental skill that is important for children to become proficient readers. This expertise can be indexed by the N1 component of ERPs at the neural level. However, the nature of N1 tuning for print is controversial in terms of onset of the latency, lateralization and the neural mechanism of the N1. This study aimed to investigate whether two groups of Chinese children could discriminate characters/charac...
2 CitationsSource
#1Wei Zhou (Capital Normal University)H-Index: 8
#2Xiaojuan Wang (SNNU: Shaanxi Normal University)H-Index: 5
Last. Hua Shu (McGovern Institute for Brain Research)H-Index: 41
view all 6 authors...
When reading a narrative text, both the dorsal and ventral visual systems areactivated. To illustrate the patterns of interactions between the dorsal and ventral visual systems in text reading, we conducted analyses of functional connectivity (FC) and effective connectivity (EC) in a left-hemispheric network for reading-driven fMRI and resting-state fMRI (rs-fMRI) data. In reading-driven fMRI (Experiment 1), we found significant FCs among the left middle frontal gyrus (MFG), the left intrapariet...
9 CitationsSource
#1Hua ZhaoH-Index: 2
#2Bao-ping ZhangH-Index: 2
Last. Peng-xiang ZuoH-Index: 2
view all 5 authors...
Several studies have been conducted to explore risk factors for dyslexia. However, most studies examining dyslexia have been skewed toward Western countries, and few have considered two nationalities simultaneously. This study focused on differences in dyslexia prevalence and potential environmental risk factors between Han and Uyghur children.A cross-sectional study was conducted in Kashgar and Aksu, cities in Xinjiang province, China. A two-stage sampling strategy was used to recruit 2,854 stu...
2 CitationsSource
#1Wei Zhou (BNU: Beijing Normal University)H-Index: 8
#2Zhichao Xia (BNU: Beijing Normal University)H-Index: 6
Last. Hua Shu (BNU: Beijing Normal University)H-Index: 41
view all 4 authors...
While there is emerging evidence from behavioral studies that visual attention skills are impaired in dyslexia, the corresponding neural mechanism (i.e. deficits in the dorsal visual region) needs further investigation. We used resting-state fMRI to explore the functional connectivity (FC) patterns of the left intraparietal sulcus (IPS) and the visual word form area (VWFA) in dyslexic children (N = 21, age mean =12) and age-matched controls (N = 26, age mean =12). The results showed that the lef...
18 CitationsSource