Comprehensive mapping of long-range interactions reveals folding principles of the human genome.

Science56.90
Volume: 326, Issue: 5950, Pages: 289 - 293
Published: Oct 9, 2009
Abstract
We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 megabase. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes. We identified an additional level of genome organization that is...
Paper Details
Title
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Published Date
Oct 9, 2009
Journal
Volume
326
Issue
5950
Pages
289 - 293
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