Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Abstract
Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages. A comprehensive metabolic map of lipopolysaccharide-activated macrophages shows upregulation of glycolytic and...
Paper Details
Title
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Published Date
Apr 11, 2013
Journal
Volume
496
Issue
7444
Pages
238 - 242
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