Many levels of control of V gene rearrangement frequency

Summary: V, D, and J gene segments rearrange at very different frequencies. As with most biological systems, there are multiple levels of control of V gene recombination frequency, and here we review some of the work from our laboratory that addresses these various control mechanisms. One of the important factors that affect non‐random V gene rearrangement frequency is the natural heterogeneity in recombination signal sequences (RSSs). Not only...