Polymorphonuclear leucocytes mediate endogenous thrombus lysis via a u-PA-dependent mechanism
Abstract
Many human thrombi lyse spontaneously without the administration of lytic drugs and cause no clinical symptoms. The mechanisms by which this occurs are incompletely understood. We found that model thrombi prepared from whole human blood in a Chandler loop also exhibited significant spontaneous lysis. Lysis was inhibited by chemical protease inhibitors, consistent with proteolysis resulting primarily from serine proteases, with a small...
Paper Details
Title
Polymorphonuclear leucocytes mediate endogenous thrombus lysis via a u-PA-dependent mechanism
Published Date
Apr 1, 2001
Volume
113
Issue
1
Pages
72 - 80
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