Pitted enamel hypoplasia in tuberous sclerosis patients and first-degree relatives

Thirty‐six families with tuberous sclerosis (TS) including 49 affected persons and 68 apparently unaffected first‐degree relatives were examined for dental abnormality. Fifty unrelated controls were similarly examined. Clinically observed multiple enamel pits (pitted enamel hypoplasia) were noted in 71% of persons with typical TS and in one out of 10 “atypical” cases. Enamel pits were rarely seen, and in small numbers only, in the control...