Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.
Abstract
Recent evidence has emphasized soluble species of amyloid-β (Aβ) and tau as pathogenic effectors in Alzheimer's disease (AD). Despite the fact that Aβ, tau, and α-synuclein (αSyn) can promote each other's aggregation, the potential contribution of soluble αSyn to AD pathogenesis is unknown. Here, we found an approximate twofold increase over controls in soluble αSyn levels in AD brains in the absence of Lewy body cytopathology. Importantly,...
Paper Details
Title
Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.
Published Date
Jul 25, 2012
Journal
Volume
32
Issue
30
Pages
10253 - 10266
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