Original paper
Attenuating gene expression (AGE) for vaccine development
Abstract
Live attenuated vaccines are adept in stimulating protective immunity. Methods for generating such vaccines have largely adopted strategies used with Salmonella enterica. Yet, when similar strategies were tested in other gram-negative bacteria, the virulence factors or genes responsible to incapacitate Salmonella often failed in providing the desired outcome. Consequently, conventional live vaccines rely on prior knowledge of the pathogen's...
Paper Details
Title
Attenuating gene expression (AGE) for vaccine development
Published Date
Jul 1, 2013
Journal
Volume
4
Issue
5
Pages
384 - 390
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Notes
History