TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells
Abstract
Papillary thyroid carcinoma (PTC) arises from the thyroid follicular epithelium and represents the most frequent thyroid malignancy. PTC is associated with gene rearrangements generating RET/PTC and TRK oncogenes, and to the BRAFV600E activating point mutation. A role of tumor-suppressor genes in the pathogenesis of PTC has not been assessed yet. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene, encoding a metalloproteinases inhibitor...
Paper Details
Title
TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells
Published Date
Feb 21, 2011
Journal
Volume
30
Issue
27
Pages
3011 - 3023
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History