Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.

Volume: 96, Issue: 1, Pages: 266 - 271
Published: Jan 5, 1999
Abstract
LXRα and -β are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile acids. Previously, we have proposed that LXRs regulate these pathways through their interaction with specific, naturally occurring oxysterols, including 22(R)-hydroxycholesterol, 24(S)-hydroxycholesterol, and 24(S),25-epoxycholesterol. Using a ligand binding assay that incorporates scintillation proximity technology to...
Paper Details
Title
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.
Published Date
Jan 5, 1999
Volume
96
Issue
1
Pages
266 - 271
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