How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?
Abstract
The early intermediates in the protein aggregation pathway, the elusive soluble aggregates, play a pivotal role in growth and maturation of ordered aggregates such as amyloid fibrils. Blocking the growth of soluble oligomers is an effective strategy to inhibit aggregation. To decipher the molecular mechanisms and develop better strategies to arrest aggregation, it is imperative to understand how the size, molecular dynamics, activity and growth...
Paper Details
Title
How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?
Published Date
Sep 25, 2008
Journal
Volume
415
Issue
2
Pages
275 - 288
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