Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells.

Volume: 111, Issue: 13, Pages: 4892 - 4897
Published: Apr 1, 2014
Abstract
Estrogen receptor-α (ERα) has central role in hormone-dependent breast cancer and its ligand-induced functions have been extensively characterized. However, evidence exists that ERα has functions that are independent of ligands. In the present work, we investigated the binding of ERα to chromatin in the absence of ligands and its functions on gene regulation. We demonstrated that in MCF7 breast cancer cells unliganded ERα binds to more than...
Paper Details
Title
Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells.
Published Date
Apr 1, 2014
Volume
111
Issue
13
Pages
4892 - 4897
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