Promotion of Morphological Transformation by di-n-butyltin Dichloride in C3H/10T1/2 Cells: Prediction by Prior Expression of Tumour Promoter-Responsive Genes

Previous studies in our laboratory have shown that chemical treatments may induce increases in proliferin gene family mRNA accumulation in cultured murine embryonic cells. Proliferin inductions are highly correlated with subsequent promotional outcomes during two-stage focus-formation assays in C3H/10T1/2 cell cultures. In work reported here, the strong affiliation between these two responses was further validated after treating cells with...