Uneven Genetic Robustness of HIV-1 Integrase

Volume: 89, Issue: 1, Pages: 552 - 567
Published: Jan 1, 2015
Abstract
Genetic robustness (tolerance of mutation) may be a naturally selected property in some viruses, because it should enhance adaptability. Robustness should be especially beneficial to viruses like HIV-1 that exhibit high mutation rates and exist in immunologically hostile environments. Surprisingly, however, the HIV-1 capsid protein (CA) exhibits extreme fragility. To determine whether fragility is a general property of HIV-1 proteins, we created...
Paper Details
Title
Uneven Genetic Robustness of HIV-1 Integrase
Published Date
Jan 1, 2015
Volume
89
Issue
1
Pages
552 - 567
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.