Neuroinflammation in Alzheimer's disease
Abstract
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide...
Paper Details
Title
Neuroinflammation in Alzheimer's disease
Published Date
Apr 1, 2015
Journal
Volume
14
Issue
4
Pages
388 - 405
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Notes
History