Comparative bioavailability of fluoxetine after transdermal and oral administration to healthy cats

To determine bioavailability, pharmacokinetics, and safety for transdermal (TD) and oral administration of fluoxetine hydrochloride to healthy cats.12 healthy mixed-breed sexually intact 1- to 4-year-old purpose-bred cats.A single-dose pharmacokinetic study involving 3 groups of 4 cats each was conducted in parallel. Fluoxetine in a formulation of pluronic lecithin organogel (PLO gel) was applied to the hairless portion of the pinnae of cats at...