Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity
Volume: 21, Issue: 6, Pages: 528 - 534
Published: May 4, 2014
Abstract
The initial stage of CRISPR-Cas immunity involves the integration of foreign DNA spacer segments into the host genomic CRISPR locus. The nucleases Cas1 and Cas2 are the only proteins conserved among all CRISPR-Cas systems, yet the molecular functions of these proteins during immunity are unknown. Here we show that Cas1 and Cas2 from Escherichia coli form a stable complex that is essential for spacer acquisition and determine the 2.3-Å-resolution...
Paper Details
Title
Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity
Published Date
May 4, 2014
Volume
21
Issue
6
Pages
528 - 534
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