Signal processing at the Ras circuit: what shapes Ras activation patterns?
Abstract
A systems biology approach is applied to gain a quantitative understanding of the integration of signalling by the small GTPase Ras. The Ras protein acts as a critical switch in response to signals that determine the cell's fate. In unstimulated cells, Ras switching between an inactive GDP-binding and active GTP-binding state is controlled by the intrinsic catalytic activities of Ras. The calculated high sensitivity of the basal Ras-GTP fraction...
Paper Details
Title
Signal processing at the Ras circuit: what shapes Ras activation patterns?
Published Date
Sep 20, 2004
Journal
Volume
1
Issue
1
Pages
104 - 113
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