Signal processing at the Ras circuit: what shapes Ras activation patterns?

Volume: 1, Issue: 1, Pages: 104 - 113
Published: Sep 20, 2004
Abstract
A systems biology approach is applied to gain a quantitative understanding of the integration of signalling by the small GTPase Ras. The Ras protein acts as a critical switch in response to signals that determine the cell's fate. In unstimulated cells, Ras switching between an inactive GDP-binding and active GTP-binding state is controlled by the intrinsic catalytic activities of Ras. The calculated high sensitivity of the basal Ras-GTP fraction...
Paper Details
Title
Signal processing at the Ras circuit: what shapes Ras activation patterns?
Published Date
Sep 20, 2004
Volume
1
Issue
1
Pages
104 - 113
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.