Analysis of Clonotype Distribution and Persistence for an Influenza Virus-Specific CD8+ T Cell Response
Abstract
The spectrum of TCR V beta usage is compared for primary and recall CD8(+)D(b)PA(224)(+) T cell responses in mice with influenza pneumonia. Single-cell RT-PCR established that the same clonotypes were present in the lymphoid tissue and in the virus-infected lung. Longitudinal analysis indicated that the memory TCR repertoire reflects the primary response, with no decrease in diversity prior to (or after) secondary challenge. The re-engagement of...
Paper Details
Title
Analysis of Clonotype Distribution and Persistence for an Influenza Virus-Specific CD8+ T Cell Response
Published Date
Apr 1, 2003
Journal
Volume
18
Issue
4
Pages
549 - 559
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