Double producers of kappa and lambda define a subset of B cells in mouse plasmacytomas
Abstract
null null Rearrangement of the light chain locus is believed to be an ordered process in which Igλ rearrangements only occur if Igκ rearrangements are found to be non-productive or self-reactive. Secondary rearrangements of the B-cell receptor (BCR) have shown, however, that rescue of abortive Igκ rearrangements or autoreactive B cells can be achieved through receptor editing using upstream V-regions as the template sequences. Since secondary...
Paper Details
Title
Double producers of kappa and lambda define a subset of B cells in mouse plasmacytomas
Published Date
Sep 1, 2000
Journal
Volume
37
Issue
12
Pages
775 - 781
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