Hepatitis B virus polymerase impairs interferon-α–induced STA T activation through inhibition of importin-α5 and protein kinase C-䆇§
Abstract
Treatment with exogenous interferon (IFN)-α is not effective in the majority of patients with chronic hepatitis B virus (HBV) infection. Recent evidence suggests that HBV has evolved strategies to block the nuclear translocation of signal transducer and activator of transcription (STAT) 1 to limit IFN-α–induced cellular antiviral responses. However, it remains unclear whether STAT1 translocation is impaired in chronic hepatitis B patients and...
Paper Details
Title
Hepatitis B virus polymerase impairs interferon-α–induced STA T activation through inhibition of importin-α5 and protein kinase C-䆇§
Published Date
Feb 1, 2013
Journal
Volume
57
Issue
2
Pages
470 - 482
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