Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy
Abstract
Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease, which in about 30% of the patients is caused by missense mutations in one allele of the β-myosin heavy chain (β-MHC) gene (MYH7). To address potential molecular mechanisms underlying the family-specific prognosis, we determined the relative expression of mutant versus wild-type MYH7-mRNA. We found a hitherto unknown mutation-dependent unequal expression of mutant to...
Paper Details
Title
Unequal allelic expression of wild-type and mutated β-myosin in familial hypertrophic cardiomyopathy
Published Date
Jul 19, 2011
Journal
Volume
106
Issue
6
Pages
1041 - 1055
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