The local administration of TNF-α and RANKL antagonist peptide promotes BMP-2-induced bone formation
Abstract
Because high doses of bone morphogenetic proteins (BMPs) are required to achieve a certain level of bone regeneration in primates, thereby causing side effects such as inflammation, combination therapies using BMPs along with agents that can reduce the required amount of BMPs have been developed. Recently, we found that subcutaneous injections of W9 peptide (W9), which has been established as a tumor necrosis factor (TNF)-α and receptor...
Paper Details
Title
The local administration of TNF-α and RANKL antagonist peptide promotes BMP-2-induced bone formation
Published Date
Feb 1, 2013
Journal
Volume
55
Issue
1
Pages
47 - 54
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Notes
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