scinapse is loading now...

Subcutaneous Abdominal Fat and Thigh Muscle Composition Predict Insulin Sensitivity Independently of Visceral Fat

Published on Oct 1, 1997in Diabetes 7.27
· DOI :10.2337/diacare.46.10.1579
Bret H. Goodpaster80
Estimated H-index: 80
(University of Pittsburgh),
F L Thaete6
Estimated H-index: 6
(University of Pittsburgh)
+ 1 AuthorsDavid E. Kelley79
Estimated H-index: 79
(University of Pittsburgh)
Abstract
Whether visceral adipose tissue has a uniquely powerful association with insulin resistance or whether subcutaneous abdominal fat shares this link has generated controversy in the area of body composition and insulin sensitivity. An additional issue is the potential role of fat deposition within skeletal muscle and the relationship with insulin resistance. To address these matters, the current study was undertaken to measure body composition, aerobic fitness, and insulin sensitivity within a cohort of sedentary healthy men ( n = 26) and women ( n = 28). The subjects, who ranged from lean to obese (BMI 19.6-41.0 kg/m2), underwent dual energy X-ray absorptiometry (DEXA) to measure fat-free mass (FFM) and fat mass (FM), computed tomography to measure cross-sectional abdominal subcutaneous and visceral adipose tissue, and computed tomography (CT) of mid-thigh to measure muscle cross-sectional area, muscle attenuation, and subcutaneous fat. Insulin sensitivity was measured using the glucose clamp technique (40 mU · m∼2 · min−1), in conjunction with [3-3H]glucose isotope dilution. Maximal aerobic power (Vo2max) was determined using an incremental cycling test. Insulin-stimulated glucose disposal ( R d) ranged from 3.03 to 16.83 mg · min−1· kg−1 FFM. R d was negatively correlated with FM ( r = -0.58), visceral fat ( r = -0.52), subcutaneous abdominal fat ( r = -0.61), and thigh fat ( r = -0.38) and positively correlated with muscle attenuation ( r = 0.48) and Vo2max ( r = 0.26, P < 0.05). In addition to manifesting the strongest simple correlation with insulin sensitivity, in stepwise multiple regression, subcutaneous abdominal fat retained significance after adjusting for visceral fat, while the converse was not found. Muscle attenuation contributed independent significance to multiple regression models of body composition and insulin sensitivity, and in analysis of obese subjects, muscle attenuation was the strongest single correlate of insulin resistance. In summary, as a component of central adiposity, subcutaneous abdominal fat has as strong an association with insulin resistance as visceral fat, and altered muscle composition, suggestive of increased fat content, is an important independent marker of insulin resistance in obesity.
  • References (0)
  • Citations (774)
Cite
References0
Newest
Cited By774
Newest
Published on Aug 18, 2019in Nutrition and Cancer 2.26
Patricia M. Sheean17
Estimated H-index: 17
(Loyola University Chicago),
Sandra L. Gomez-Perez1
Estimated H-index: 1
(Rush University Medical Center)
+ 5 AuthorsLomasney Lm11
Estimated H-index: 11
(Loyola University Medical Center)
AbstractLimited data exist regarding body composition and associated patient-reported outcomes for women with metastatic BC. Demographic, clinical, blood, and questionnaire data were collected to quantify body composition and explore associations with symptoms, inflammation, and quality of life (QOL) in 41 women with ER + metastatic BC. Diagnostic/surveillance computed tomography (CT) images including the third lumbar region (L3) were obtained to evaluate skeletal muscle (SM) quantity and qualit...
Source Cite
Published on May 23, 2019in Journal of Nutrition Health & Aging 2.87
Akito Yoshiko5
Estimated H-index: 5
(Nagoya University),
Takashi Kaji2
Estimated H-index: 2
+ 3 AuthorsHiroshi Akima31
Estimated H-index: 31
(Nagoya University)
Objectives To assess the effects of 24 months training on muscle quality, size, strength, and gait abilities in older adults who need long-term care. Design: Non-randomized controlled trial Setting: Kawai Rehabilitation Center and Kajinoki Medical Clinic.
Source Cite
Published on May 1, 2019in Psychoneuroendocrinology 4.73
Robin Ortiz1
Estimated H-index: 1
(Johns Hopkins University School of Medicine),
Bjoern Kluwe (Ohio State University)+ 6 AuthorsJoshua J. Joseph6
Estimated H-index: 6
(Ohio State University)
Abstract Background Serum cortisol levels have been associated with type 2 diabetes (T2D). However, the role of cortisol in glycemia and T2D is not fully elucidated among African Americans (AAs). We hypothesized that among AAs morning serum cortisol would be positively associated with glycemic measures and prevalent T2D. Methods We examined the cross-sectional association of baseline morning serum cortisol with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homeostasis model assessment of...
Source Cite
Published on Mar 1, 2019in Surgery 3.57
Cyrus Jahansouz6
Estimated H-index: 6
(University of Minnesota),
Hongliang Xu5
Estimated H-index: 5
(University of Minnesota)
+ 10 AuthorsMichael Dennis Jensen68
Estimated H-index: 68
Abstract Background Serum concentrations of fatty acid binding protein 4, an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study were to assess relationships among Roux-en-Y gastric bypass, intensive lifestyle modification and medical management protocol, fatty acid binding protein 4, and metabolic parameters in obese patients with severe type 2 diabetes mellitus; and to evaluate the relative contribution ...
Source Cite
Published on Mar 1, 2019in Clinical Endocrinology 3.08
Emmanuel Kwaku Ofori1
Estimated H-index: 1
(University of Lausanne),
Sonia Conde Alonso2
Estimated H-index: 2
(University of Lausanne)
+ 7 AuthorsFrancesca Amati18
Estimated H-index: 18
(University of Lausanne)
Source Cite
Published on Feb 1, 2019in BJUI 4.69
Dennis Taafe50
Estimated H-index: 50
(Edith Cowan University),
Daniel A. Galvão31
Estimated H-index: 31
(Edith Cowan University)
+ 7 AuthorsRobert U. Newton91
Estimated H-index: 91
Objectives: To examine whether it is more efficacious to commence exercise medicine in men with prostate cancer at the onset of androgen‐deprivation therapy (ADT) rather than later on during treatment to preserve bone and soft‐tissue composition, as ADT results in adverse effects including: reduced bone mineral density (BMD), loss of muscle mass, and increased fat mass (FM). Patients and methods: In all, 104 patients with prostate cancer, aged 48–84 years initiating ADT, were randomised to immed...
1 Citations Source Cite
Published on Feb 1, 2019in Physiological Reports
Tanja Sjöros2
Estimated H-index: 2
(University of Turku),
Virva Saunavaara9
Estimated H-index: 9
(Turku University Hospital)
+ 6 AuthorsKari K. Kalliokoski32
Estimated H-index: 32
(University of Turku)
Source Cite
Published on Jan 23, 2019in Diabetic Medicine 3.13
Louise Goff12
Estimated H-index: 12
(King's College London)
Source Cite
Published on Jan 1, 2019
Frédéric Capel13
Estimated H-index: 13
,
Alexandre Pinel4
Estimated H-index: 4
,
Stéphane Walrand14
Estimated H-index: 14
Source Cite
Published on Jan 1, 2019in Diabetes & Metabolism Journal
Eugene Han7
Estimated H-index: 7
(Keimyung University),
Nan Hee Cho1
Estimated H-index: 1
(Keimyung University)
+ 1 AuthorsHye Soon Kim7
Estimated H-index: 7
(Keimyung University)
Source Cite