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Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia.

Published on Nov 1, 2004in Clinical Biochemistry2.43
· DOI :10.1016/j.clinbiochem.2004.06.013
Emre Sarandol20
Estimated H-index: 20
(Uludağ University),
Özlem aŞafak1
Estimated H-index: 1
(Uludağ University)
+ 1 AuthorsGürkan Uncu13
Estimated H-index: 13
(Uludağ University)
Cite
Abstract
Abstract Objectives. Lipoprotein oxidation has been implicated in the pathogenesis of preeclampsia and paraoxonase, an antioxidant enzyme shown to protect lipoproteins from being oxidized. The aim of the present study was to evaluate oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia. Design and methods. Twenty-one women with mild preeclampsia, 21 women with severe preeclampsia, and 20 women with normal uncomplicated pregnancy were included in this study. Serum malondialdehyde (MDA) level, an indicator of lipid peroxidation, was measured by high-performance liquid chromatography (HPLC). The oxidizability of apolipoprotein B-containing lipoproteins was evaluated by copper-induced in vitro peroxidation of the isolated fraction of apolipoprotein B-containing lipoproteins coupled with the thiobarbituric acid-reactive substances assay and expressed as the difference between copper-treated MDA and basal MDA (ΔMDA). The serum paraoxonase and arylesterase activities were determined spectrophotometrically. Results. Serum MDA and ΔMDA levels of apolipoprotein B-containing lipoproteins were significantly higher in both mild and severe preeclampsia groups than in the normal pregnant group. Serum paraoxonase and arylesterase activities were not significantly different among the study groups. Conclusions. Enhancement in oxidizability of apolipoprotein B-containing lipoproteins accompanying with dyslipidemia and increased serum MDA levels suggests that those lipoproteins play a role in the pathogenesis of preeclampsia. Further studies are needed to investigate serum paraoxonase activity in women with normal pregnancies and preeclampsia.
  • References (49)
  • Citations (23)
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References49
Newest
Published on Apr 23, 2008in Clinical Genetics4.10
Srdjan Djurovic53
Estimated H-index: 53
(University of Oslo),
Rune Schjetlein6
Estimated H-index: 6
+ 3 AuthorsKåre Berg52
Estimated H-index: 52
(University of Oslo)
This study was performed to investigate the possible association between preeclampsia and the plasma concentrations of Lp(a) lipoprotein and TGF-β 1 in a large series of patients. Additionally, correlation between the concentrations of these molecules and the severity of preeclampsia or fetal growth retardation was evaluated. Following clinical examination and biochemical analyses, both electroimmunoassay and RIA technique were used for quantitative determinations of plasma Lp(a) lipoprotein. EL...
Selahattin Kumru15
Estimated H-index: 15
(Fırat University),
Suleyman Aydin30
Estimated H-index: 30
(Fırat University)
+ 1 AuthorsZeynep Özcan4
Estimated H-index: 4
(Fırat University)
Abstract Objective: To determine the serum lipid profile, the activity of paraoxonase (PON, the lipophilic antioxidant component of HDL-cholesterol), and alterations of the arylesterase activity in preeclamptic women. Study Design: This cross-sectional study included 28 severe preeclamptic, and 24 healthy pregnant women. Fasting venous blood samples were collected during the antepartum period for spectrophotometric determination of the PON and arylesterase activities. Results: In the severe pree...
Published on Oct 1, 2003in Clinical Biochemistry2.43
Mustafa Cekmen21
Estimated H-index: 21
(Kocaeli University),
Ayse Binnur Erbagci13
Estimated H-index: 13
(University of Gaziantep)
+ 6 AuthorsSevinc Kuskay4
Estimated H-index: 4
(Kocaeli University)
Abstract Objectives Aim of this study was to evaluate implication of pregnancy induced hypertension on maternal plasma lipid, lipoprotein, apolipoprotein concentrations and lipid peroxidation products by a comparison of normal pregnancy vs. preeclampsia. Design and methods Thirty-four women with preeclampsia and 32 healthy pregnant women (controls) in the third trimester were recruited for this study. Results In the preeclamptic group plasma total triglyceride, low density lipoprotein cholestero...
Published on Apr 1, 2003in Archives of Gynecology and Obstetrics2.20
Zehra Serdar14
Estimated H-index: 14
,
Gür E1
Estimated H-index: 1
+ 2 AuthorsEmre Sarandol20
Estimated H-index: 20
The aim of this study was to evaluate the lipid and protein oxidation and antioxidant function in preeclampsia patients and in normotensive pregnant women as well as to assess an association with the severity of the disease. The study was carried out in 30 patients with mild preeclampsia 30 with severe preeclampsia and in 50 normotensive pregnant women during the third trimester of pregnancy. Lipid peroxides in serum placental and decidual tissues and serum protein carbonyls and some of the anti...
Published on Apr 1, 2003in Archives of Gynecology and Obstetrics2.20
Ahmet Var14
Estimated H-index: 14
(Celal Bayar University),
Kemal Kusçu2
Estimated H-index: 2
(Celal Bayar University)
+ 4 AuthorsSemra Oruç9
Estimated H-index: 9
(Celal Bayar University)
Atherosis is accepted to underlie the pathogenesis of preeclampsia, therefore we aimed to determine malonyldialdehyde (MDA) levels as a marker of lipid peroxidation, and lipoprotein(a) (Lp(a)), apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) levels as a marker of atherogenic profile in preeclamptic and normal pregnant women. Twenty preeclamptic and 20 gestational-age matched normal pregnant patients were enrolled in the study, mean gestational ages for the preeclamptic and the control ...
Published on Mar 1, 2003in The Journal of Clinical Endocrinology and Metabolism5.61
Karl Winkler25
Estimated H-index: 25
,
Birgit Wetzka8
Estimated H-index: 8
+ 6 AuthorsWinfried März87
Estimated H-index: 87
(University of Graz)
Disorders of the lipoprotein metabolism are a major cause of endothelial dysfunction that may result in hypertension and proteinuria, clinical hallmarks of preeclampsia (PE). Lipoproteins and low-density lipoprotein (LDL) subfractions were investigated in 15 women with severe PE and compared with 23 women with a normal course of pregnancy. Compared with normal pregnancy, in PE apolipoprotein (apo)B in very low-density lipoprotein was increased by 76% (P = 0.008), and the triglyceride content of ...
Published on Jan 1, 2003in Acta Obstetricia et Gynecologica Scandinavica2.74
Ofer Fainaru11
Estimated H-index: 11
(Tel Aviv Sourasky Medical Center),
Dov Lichtenberg33
Estimated H-index: 33
(TAU: Tel Aviv University)
+ 3 AuthorsMichael J. Kupferminc32
Estimated H-index: 32
(Tel Aviv Sourasky Medical Center)
Background. Several reports suggest preeclampsia to be associated with oxidative stress. In view of potential experimental artifacts in these studies, we tested the effect of preeclampsia on the oxidizibility of maternal serum lipids, using an optimized ex vivo method. Methods. This prospective study included 28 pregnant women with preeclampsia and 28 women matched for maternal and gestational age with normal pregnancies. Venous blood was drawn from the consenting women. Serum levels of lipid pe...
Published on Jun 1, 2002in Atherosclerosis4.25
Luís Belo26
Estimated H-index: 26
(University of Porto),
Muriel J. Caslake58
Estimated H-index: 58
(Glasgow Royal Infirmary)
+ 4 AuthorsIrene Rebelo21
Estimated H-index: 21
(University of Porto)
Abstract The aim of this study was to evaluate changes in lipids, apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first ( n =64), second ( n =48) and third ( n =67) trimesters and puerperium ( n =32) of normal pregnancies. Samples from preeclamptic women were obtained in the third trimester ( n =51) and in puerperium ( n =26). As normal pr...
Published on Mar 1, 2002in Journal of Human Hypertension1.94
E Escobar1
Estimated H-index: 1
(University of Chile)
The association of hypertension and coronary heart disease is a frequent one. There are several pathophysiologic mechanisms which link both diseases. Hypertension induces endothelial dysfunction, exacerbates the atherosclerotic process and it contributes to make the atherosclerotic plaque more unstable. Left ventricular hypertrophy, which is the usual complication of hypertension, promotes a decrease of 'coronary reserve' and increases myocardial oxygen demand, both mechanisms contributing to my...
Published on Jan 1, 2001in Acta Obstetricia et Gynecologica Scandinavica2.74
Robin S. Bowen1
Estimated H-index: 1
,
J. Moodley26
Estimated H-index: 26
(University of Natal)
+ 1 AuthorsAnnette J. Theron23
Estimated H-index: 23
(University of Pretoria)
Background. The objective of this study was to test the hypothesis that maternal plasma, cord plasma and placental tissue lipid peroxidation products are increased and antioxidants are decreased in women with pre-eclampsia. Methods. Placenta, maternal and cord plasma were collected at delivery from 29 normal, 21 pre-eclamptic and six eclamptic women. Plasma was collected from 21 non-pregnant matched controls. The analyses were measured by HPLC and colorimetric assay. Results. Plasma maternal con...
Cited By23
Newest
Published on Jul 4, 2019in International Journal of Molecular Sciences4.18
Shu-Wing Ng11
Estimated H-index: 11
,
Sam G. Norwitz , Errol R. Norwitz43
Estimated H-index: 43
Iron is an essential element for the survival of most organisms, including humans. Demand for iron increases significantly during pregnancy to support growth and development of the fetus. Paradoxically, epidemiologic studies have shown that excessive iron intake and/or high iron status can be detrimental to pregnancy and is associated with reproductive disorders ranging from endometriosis to preeclampsia. Reproductive complications resulting from iron deficiency have been reviewed elsewhere. Her...
Published on Aug 1, 2018in Archives of Gynecology and Obstetrics2.20
Yael Einbinder2
Estimated H-index: 2
(TAU: Tel Aviv University),
Tal Biron-Shental12
Estimated H-index: 12
(TAU: Tel Aviv University)
+ 6 AuthorsTali Zitman-Gal1
Estimated H-index: 1
(TAU: Tel Aviv University)
Purpose To evaluate (a) the properties of high-density lipoproteins (HDL)/cholesterol, which include apolipoprotein A-1 (ApoA1) and paraoxonase1 (PON1), both are negative predictors of cardiovascular risk and (b) HDL function, among women with preeclampsia (PE). PE is a multi-system disorder, characterized by onset of hypertension and proteinuria or other end-organ dysfunction in the second half of pregnancy. Preeclampsia is associated with increased risk for later cardiovascular disease. The in...
Published on Jan 1, 2014in International Journal of Endocrinology2.29
Ying Huang1
Estimated H-index: 1
,
Yong Zhao3
Estimated H-index: 3
+ 5 AuthorsAiming Wang2
Estimated H-index: 2
Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process. Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal ...
Published on Jan 1, 2013in Medical Science Monitor1.98
Marzena Laskowska9
Estimated H-index: 9
(Medical University of Lublin),
Katarzyna Laskowska7
Estimated H-index: 7
+ 1 AuthorsJan Oleszczuk17
Estimated H-index: 17
(Medical University of Lublin)
Background The aim of this study was to determine the maternal serum concentrations of eNOS, ADMA, and homocysteine in preeclamptic pregnancies.
Published on Jan 1, 2013in Mediators of Inflammation3.54
Şerefden Açıkgöz6
Estimated H-index: 6
,
Ülkü Bayar9
Estimated H-index: 9
+ 4 AuthorsVildan Sumbuloglu8
Estimated H-index: 8
In vitro literature studies have suggested that atherosclerotic oxidized low density lipoprotein (OxLDL) inhibits trophoblast invasion. The objective of this study was to determine the levels of OxLDL and to examine the relationship between antioxidative estradiol, estriol, and prooxidative progestin in normal and preeclamptic placental tissues and measure the serum activity of antioxidative paraoxonase (PON1). The study included 30 preeclamptic and 32 normal pregnant women. OxLDL was determined...
Published on Aug 1, 2012in Journal of Obstetrics and Gynaecology0.59
Bulent Demir7
Estimated H-index: 7
,
S Demir3
Estimated H-index: 3
+ 4 AuthorsYuksel Kocyigit12
Estimated H-index: 12
(Dicle University)
Nitric oxide (NO) contributes to vasodilatation that is observed during normal pregnancy. Hyperhomocysteinaemia (HHcy) is a vascular risk factor associated with placental microvascular diseases and pre-eclampsia. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of endothelial nitric oxide synthase (NOS) has been linked to endothelial dysfunction. Maternal ADMA has been reported to be higher in women with pre-eclampsia and HHcy leads to accumulation of ADMA. The aim of this presented s...
Published on Jun 1, 2012
Norma Serrano-Díaz4
Estimated H-index: 4
(UNAB: Autonomous University of Bucaramanga),
Sandra Milena Acevedo2
Estimated H-index: 2
(UNAB: Autonomous University of Bucaramanga)
+ 5 AuthorsMaría Carolina Páez Leal1
Estimated H-index: 1
(UNAB: Autonomous University of Bucaramanga)
Preeclampsia (PE) is a multisystemic disorder unique to human pregnancy and responsible for about 44,000 maternal deaths worldwide. This disease is associated with multiple complications for both mother and fetus; however, its etiology is not totally clear and it has therefore been difficult to define valid prediction strategies. PE is a complex disease and it shares different risk factors with cardiovascular disease, such as obesity, hypertension, insulin resistance and dyslipidemia, evidencing...
Published on Jan 1, 2012
Norma Serrano-Díaz4
Estimated H-index: 4
(UNAB: Autonomous University of Bucaramanga),
Sandra Milena Acevedo (Andrés Bello National University)+ 5 AuthorsMaría Carolina Páez Leal1
Estimated H-index: 1
(UNAB: Autonomous University of Bucaramanga)
La Preeclampsia (PE) es un trastorno multisistemico, exclusivo de la gestacion humana y responsable de aproximadamente 44.000 muertes maternas anuales a nivel mundial; esta enfermedad esta asociada a multiples complicaciones tanto en la madre como en el feto, sin embargo, su etiologia no se encuentra totalmente dilucidada y en consecuencia ha sido dificil definir estrategias validas de prediccion. La PE es una enfermedad compleja y comparte diferentes factores de riesgo con las enfermedades card...
Published on Dec 1, 2011in Archives of Gynecology and Obstetrics2.20
Habibe Genc11
Estimated H-index: 11
(Istanbul University),
Hafize Uzun34
Estimated H-index: 34
(Istanbul University)
+ 4 AuthorsOnur Guralp12
Estimated H-index: 12
(Istanbul University)
Aim The aim of this study is to determine the predictive values of oxidative stress markers and antioxidants in the development of preeclampsia between 10–14 and also at 20–24 weeks of gestation, after the completion of vascular transformation.
Published on Aug 1, 2011in Journal of International Medical Research1.35
Bulent Demir7
Estimated H-index: 7
,
S Demir3
Estimated H-index: 3
+ 5 AuthorsG Toprak1
Estimated H-index: 1
(Dicle University)
Serum paraoxonase 1 (PON1) activity and the oxidation of lipoproteins were investigated in 35 women with pre-eclampsia and in 35 healthy control women with normal pregnancies. Blood pressure, body mass index (BMI), serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (a) (Lp[a]), and PON1 activity were assessed. There were no significant between-group differences in subj...