A Role of Chondroitin Sulfate Glycosaminoglycan Binding Site in α4β1 Integrin-mediated Melanoma Cell Adhesion

We have previously reported that α4β1 (but not α5β1) integrin-mediated melanoma cell adhesion is inhibited by removal of cell surface chondroitin sulfate glycosaminoglycan (CSGAG), suggesting that melanoma chondroitin sulfate proteoglycan plays a role in modulating the adhesive function of α4β1 integrin. In the current study, we demonstrated that α4β1 integrin binds to CSGAG. We have identified a peptide from within α4 integrin termed SG1...