The three-dimensional structure of an intact monoclonal antibody for canine lymphoma.

Nature64.80
Volume: 360, Issue: 6402, Pages: 369 - 372
Published: Nov 26, 1992
Abstract
CRYSTAL structures of Fab antibody fragments determined by X-ray diffraction characteristically feature four-domain, β-barrel arrangements1–3. A human antibody Fc fragment has also been found to have four β-barrel domains4. The structures of a few intact antibodies have been solved5–8: in two myeloma proteins, the flexible hinge regions that connect the Fc to the Fab segments were deleted5,6 so the molecules were non-functional, structurally...
Paper Details
Title
The three-dimensional structure of an intact monoclonal antibody for canine lymphoma.
Published Date
Nov 26, 1992
Journal
Volume
360
Issue
6402
Pages
369 - 372
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