Activation of TRPA1 by membrane permeable local anesthetics

Volume: 7, Issue: 1, Pages: 62 - 62
Published: Aug 23, 2011
Abstract
Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na+ channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demonstrated that LA-evoked activation of sensory neurons is mediated by the capsaicin receptor TRPV1, and, to a lesser extent by the irritant receptor TRPA1. LA-induced activation and sensitization of TRPV1 involves a domain that is similar,...
Paper Details
Title
Activation of TRPA1 by membrane permeable local anesthetics
Published Date
Aug 23, 2011
Volume
7
Issue
1
Pages
62 - 62
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