eIF2B, a mediator of general and gene-specific translational control
Abstract
eIF2B (eukaryotic initiation factor 2B) is a multisubunit protein that is required for protein synthesis initiation and its regulation in all eukaryotic cells. Mutations in eIF2B have also recently been found to cause a fatal human disease called CACH (childhood ataxia with central nervous system hypomyelination) or VWM (vanishing white matter disease). This review provides a general background to translation initiation and mechanisms known to...
Paper Details
Title
eIF2B, a mediator of general and gene-specific translational control
Published Date
Oct 26, 2005
Volume
33
Issue
6
Pages
1487 - 1492
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