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Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice.

Published on Jul 1, 2015in The FASEB Journal5.391
· DOI :10.1096/fj.14-266239
Leonie Hussaarts8
Estimated H-index: 8
(LUMC: Leiden University Medical Center),
Noemí García-Tardón2
Estimated H-index: 2
(LUMC: Leiden University Medical Center)
+ 9 AuthorsBruno Guigas33
Estimated H-index: 33
(LUMC: Leiden University Medical Center)
Sources
Abstract
Chronic low-grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest natural inducers of type 2 immune responses, and short-lived infection with rodent nematodes was reported to improve glucose tolerance in obese mice. Here, we investigated the effects of chronic infection (12 weeks) with Schistosoma mansoni, a helminth that infects millions of humans worldwide, on whole-body metabolic homeostasis and white adipose tissue (WAT) immune cell composition in high-fat diet-induced obese C57BL/6 male mice. Our data indicate that chronic helminth infection reduced body weight gain (−62%), fat mass gain (−89%), and adipocyte size; lowered whole-body insulin resistance (−23%) and glucose intolerance (−16%); and improved peripheral glucose uptake (+25%) and WAT insulin sensitivity. Analysis of immune cell composition by flow cytometry and quantitative PCR (qPCR) revealed that S. mansoni promoted strong increases in WAT eosinophils and alt...
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